Assassin's Creed III
The plot begins in the present day with Desmond, his father William, Rebecca Crane, and Shaun Hastings finding the Grand Temple in a cave in Turin, New York. Using an Ezio's Apple of Eden to access the structure, Desmond activates a large portion of the equipment, as well as a timer indicating when the Second Disaster is predicted to occur, on December 21, 2012. His mind then falls into a fugue state, in which he relives some significant memories of his ancestor, Haytham Kenway.
During a production at the London Theatre Royal, Haytham murders a man named Miko and steals a medallion which he and his associates believe allows access to a storehouse for "those who came before". After Haytham returns with the medallion, he is dispatched to the British American colonies to find the storehouse.